Early and differential diagnosis

VPH-DARE@IT will deliver the first patient-specific predictive models for early differential diagnosis of dementias and their evolution

The DementiA Research Enabled by IT (VPH-DARE@IT) project is a Virtual Physiological Human initiative that tackles the most pressing unmet clinical needs in this syndrome: we respond to the brief to provide early and differential diagnosis and management of the onset and progression of dementias, by integrating, in a truly multidisciplinary manner, heterogeneous data from individuals and popula-tions, genetic, biochemical and metabolic pathway models, mechanistic and phenomenological multiscale imaging/modelling paradigms and sophisticated information processing tools to deliver highly innovative clinical decision support systems.
By bringing together new knowledge and innovative methods in these fields, we will deliver the first ever model that can account simultaneously for the patient-specific multiscale biophysical, biochemical and biomechanical brain context, as well for a number of heterogeneous genetic, clinical, demographic, lifestyle and other environmental factors.
We shall investigate a number of observed and speculated links, including the effect of metabolic syn-drome, diabetes, dietary habits, exercise, pulmonary conditions, and how the effect these conditions have on the ageing brain influences onset and evolution of dementia.

This biomedical research and decision support platform will be underpinned by access to a cadre of almost a dozen databases of previously collected international cross-sectional and longitudinal studies (totalling over 9,000 subjects), includ-ing exclusive access to an invaluable longitudinal population database that has tracked the development of dementia in nearly 15,000 indi-viduals for over 20 years and is still on-going (Rotterdam Study).

This distinctive integration of innovative data analysis and modelling paradigms and access to state-of-the-art studies puts this consortium in a uniquely favourable position for making a real and measurable breakthrough in fighting the colossal health and societal burden resulting from dementias.