Publications

Journals

1.       Achterberg H, van der Lijn F, den Heijer T, Vernooij M, Ikram M, Niessen W, de Bruijne M: Hippocampal shape is predictive for the development of dementia in a normal, elderly population. Human Brain Mapping 2014, 35(5):2359-2371.

2.       Adams H, Verhaaren B, Vrooman H, Uitterlinden A, Hofman A, van Duijn C, van der Lugt A, Niessen W, Vernooij M, Ikram M: TMEM106B Influences Volume of Left-Sided Temporal Lobe and Interhemispheric Structures in the General Population. Biological Psychiatry 2014, 76(6):503-508.

3.       Akoudad S, Ikram M, Koudstaal P, Hofman A, Niessen W, Greenberg S, van der Lugt A, Vernooij M: Cerebral Microbleeds Are Associated with the Progression of Ischemic Vascular Lesions. Cerebrovascular Diseases 2014, 37(5):382-388.

4.       Alexander Schmidt-Richberg, Ricardo Guerrero, Christian Ledig, Helena Molina-Abril, Frangi AF, Rueckert D: Multi-stage biomarker models for progression estimation in Alzheimer’s disease. Information Processing in Medical Imaging (IPMI) 2015.

5.       Bron E, Steketee R, Houston G, Oliver R, Achterberg H, Loog M, van Swieten J, Hammers A, Niessen W, Smits Met al: Diagnostic Classification of Arterial Spin Labeling and Structural MRI in Presenile Early Stage Dementia. Human Brain Mapping 2014, 35(9):4916-4931.

6.       Burgos N, Cardoso M, Thielemans K, Modat M, Pedemonte S, Dickson J, Barnes A, Ahmed R, Mahoney C, Schott Jet al: Attenuation Correction Synthesis for Hybrid PET-MR Scanners: Application to Brain Studies. Ieee Transactions on Medical Imaging 2014, 33(12):2332-2341.

7.       Cash DM, Rohrer JD, Ryan NS, Ourselin S, Fox NC: Imaging endpoints for clinical trials in Alzheimer's disease. Alzheimers Res Ther 2014, 6(9):87.

8.       Daga P, Pendse T, Modat M, White M, Mancini L, Winston G, McEvoy A, Thornton J, Yousry T, Drobnjak I: Susceptibility artefact correction using dynamic graph cuts: Application to neurosurgery. Medical Image Analysis 2014, 18(7):1132-1142.

9.       de Bruijn R, Akoudad S, Cremers L, Hofman A, Niessen W, van der Lugt A, Koudstaal P, Vernooij M, Ikram M: Determinants, MRI Correlates, and Prognosis of Mild Cognitive Impairment: The Rotterdam Study. Journal of Alzheimers Disease 2014, 42:S239-S249.

10.   de Bruijn R, Portegies M, Leening M, Bos M, Hofman A, van der Lugt A, Niessen W, Vernooij M, Franco O, Koudstaal Pet al: Subclinical cardiac dysfunction increases the risk of stroke and dementia The Rotterdam Study. Neurology 2015, 84(8):833-840.

11.   de Groot M, Ikram MA, Akoudad S, Krestin GP, Hofman A, van der Lugt A, Niessen WJ, Vernooij MW: Tract-specific white matter degeneration in aging: The Rotterdam Study. Alzheimers Dement 2015, 11(3):321-330.

12.   De Marco M, Clough PJ, Dyer CE, Vince RV, Waby JS, Midgley AW, A V: Apolipoprotein E Ɛ4 allele modulates the immediate impact of acute exercise on prefrontal function. Behavior Genetics 2015, 45:106-116.

13.   Di Marco L, Marzo A, Munoz-Ruiz M, Ikram M, Kivipelto M, Ruefenacht D, Venneri A, Soininen H, Wanke I, Ventikos Yet al: Modifiable Lifestyle Factors in Dementia: A Systematic Review of Longitudinal Observational Cohort Studies. Journal of Alzheimers Disease 2014, 42(1):119-135.

14.   Di Marco LY, Venneri A, Farkas E, Evans PC, Marzo A, AF F: Vascular dysfunction in the pathogenesis of Alzheimer’s disease – A review of endothelium-mediated mechanisms and ensuing vicious circles. Neurobiology of Disease 2015.

15.   Di Marco LY, Farkas E, Martin C, Venneri A, Frangi AF: Is Vasomotion in Cerebral Arteries Impaired in Alzheimer's Disease? J Alzheimers Dis 2015.

16.   Enger R, Tang W, Vindedal GF, Jensen V, Johannes Helm P, Sprengel R, Looger LL, Nagelhus EA: Dynamics of Ionic Shifts in Cortical Spreading Depression. Cereb Cortex 2015.

17.   Gundersen G, Vindedal G, Skare O, Nagelhus E: Evidence that pericytes regulate aquaporin-4 polarization in mouse cortical astrocytes. Brain Structure & Function 2014, 219(6):2181-2186.

18.   Hadjistassou C, Bejan A, Ventikos Y: Cerebral oxygenation and optimal vascular brain organization. J R Soc Interface 2015, 12: 20150245.

19.   Haj-Yasein NN, Bugge CE, Jensen V, Ostby I, Ottersen OP, Hvalby O, Nagelhus EA: Deletion of aquaporin-4 increases extracellular K concentration during synaptic stimulation in mouse hippocampus. Brain Struct Funct 2014.

20.   Hall A, Mattila J, Koikkalainen J, Lojonen J, Wolz R, Scheltens P, Frisoni G, Tsolaki M, Nobili F, Freund-Levi Yet al: Predicting Progression from Cognitive Impairment to Alzheimer's Disease with the Disease State Index. Current Alzheimer Research 2015, 12(1):69-79.

21.   Hall A, Munoz-Ruiz M, Mattila J, Koikkalainen J, Tsolaki M, Mecocci P, Kloszewska I, Vellas B, Lovestone S, Visser Pet al: Generalizability of the Disease State Index Prediction Model for Identifying Patients Progressing from Mild Cognitive Impairment to Alzheimer's Disease. Journal of Alzheimers Disease 2015, 44(1):79-92.

22.   Heuser K, Szokol K, Steinhauser C, Jensen V, Enger R, Tang W, Tauboll E, Nagelhus E: CHANGE IN ASTROCYTIC CA(2+) RESPONSE DURING THE LATENT PERIOD OF EPILEPTOGENESIS IN THE ADULT MOUSE. Epilepsia 2014, 55:230-231.

23.   Hilal S, Ong Y, Cheung C, Tan C, Venketasubramanian N, Niessen W, Vrooman H, Anuar A, Chew M, Chen Cet al: Microvascular network alterations in retina of subjects with cerebral small vessel disease. Neuroscience Letters 2014, 577:95-100.

24.   Hilal S, Saini M, Tan C, Catindig J, Dong Y, Holandez R, Niessen W, Vrooman H, Ting E, Wong Tet al: Intracranial Stenosis, Cerebrovascular Diseases, and Cognitive Impairment in Chinese. Alzheimer Disease & Associated Disorders 2015, 29(1):12-17.

25.   Hilal S, Saini M, Tan C, Catindig J, Dong Y, Leon L, Niessen W, Vrooman H, Wong T, Chen Cet al: Ankle-Brachial Index, Cognitive Impairment and Cerebrovascular Disease in a Chinese Population. Neuroepidemiology 2014, 42(2):131-138.

26.   Hilal S, Saini M, Tan C, Catindig J, Koay W, Niessen W, Vrooman H, Wong T, Chen C, Ikram Met al: Cerebral Microbleeds and Cognition The Epidemiology of Dementia in Singapore Study. Alzheimer Disease & Associated Disorders 2014, 28(2):106-112.

27.   Hoogendam Y, van der Geest J, Niessen W, van der Lugt A, Hofman A, Vernooij M, Ikram M: The Role of Cerebellar Volume in Cognition in the General Elderly Population. Alzheimer Disease & Associated Disorders 2014, 28(4):352-357.

28.   Hoogendam Y, van der Lijn F, Vernooij M, Hofman A, Niessen W, van der Lugt A, Ikram M, van der Geest J: Older age relates to worsening of fine motor skills: a population-based study of middle-aged and elderly persons. Frontiers in Aging Neuroscience 2014, 6.

29.   Leung K, van der Lijn F, Vrooman H, Sturkenboom M, Niessen W: IT Infrastructure to Support the Secondary Use of Routinely Acquired Clinical Imaging Data for Research. Neuroinformatics 2015, 13(1):65-81.

30.   Loehrer E, Ikram M, Akoudad S, Vrooman H, van der Lugt A, Niessen W, Hofman A, Vernooij M: Apolipoprotein E genotype influences spatial distribution of cerebral microbleeds. Neurobiology of Aging 2014, 35(4):899-905.

31.   Mahoney C, Simpson I, Nicholas J, Fletcher P, Downey L, Golden H, Clark C, Schmitz N, Rohrer J, Schott J: Longitudinal Diffusion Tensor Imaging in Frontotemporal Dementia. Annals of Neurology 2015, 77(1):33-46.

32.   Manning E, Barnes J, Cash D, Bartlett J, Leung K, Ourselin S, Fox N: APOE ε4 Is Associated with Disproportionate Progressive Hippocampal Atrophy in AD. PLoS One 20174, 9(5).

33.   Manning EN, Barnes J, Cash DM, Bartlett JW, Leung KK, Ourselin S, Fox NC, Alzheimer's Disease NeuroImaging I: APOE epsilon4 is associated with disproportionate progressive hippocampal atrophy in AD. PLoS One 2014, 9(5):e97608.

34.   Melbourne A, Kendall G, Cardoso M, Gunny R, Robertson N, Marlow N, Ourselin S: Preterm birth affects the developmental synergy between cortical folding and cortical connectivity observed on multimodal MRI. Neuroimage 2014, 89:23-34.

35.   Melbournen A, Kendall G, Cardoso M, Gunny R, Robertson N, N M, S O: Preterm birth affects the developmental synergy between cortical folding and cortical connectivity observed on multimodal MRI. Neuroimage 2014, 89:23-34.

36.   Nagelhus EA: Research into glia and epilepsy. Tidsskr Nor Laegeforen 2014, 134(1):6.

37.   Ong Y, Hilal S, Cheung C, Venketasubramanian N, Niessen W, Vrooman H, Anuar A, Chew M, Chen C, Wong Tet al: Retinal neurodegeneration on optical coherence tomography and cerebral atrophy. Neuroscience Letters 2015, 584:12-16.

38.   Orasanu E, Melbourne A, Cardoso M, Modat M, Taylor A, Thayyil S, Ourselin S: Brain volume estimation from post-mortem newborn and fetal MRI. Neuroimage-Clinical 2014, 6:438-444.

39.   Papma J, de Groot M, de Koning I, Mattace-Raso F, van der Lugt A, Vernooij M, Niessen W, van Swieten J, Koudstaal P, Prins Net al: Cerebral Small Vessel Disease Affects White Matter Microstructure in Mild Cognitive Impairment. Human Brain Mapping 2014, 35(6):2836-2851.

40.   Parker C, Deligianni F, Cardoso M, Daga P, Modat M, Dayan M, Clark C, Ourselin S, Clayden J: Consensus between Pipelines in Structural Brain Networks. Jama Neurology 2014, 9(10).

41.   Rangroo Thrane V, Thrane AS, Wang F, Cotrina ML, Smith NA, Chen M, Xu Q, Kang N, Fujita T, Nagelhus EAet al: Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering. Nature medicine 2013, 19(12):1643-1648.

42.   Rohrer J, Nicholas J, Cash D, van Swieten J, Dopper E, Jiskoot L, van Minkelen R, Rombouts S, Cardoso M, Clegg Set al: Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis. Lancet Neurology 2015, 14(3):253-262.

43.   Schmidt-Richberg A, Ledig C, Moren RG, Molina-Abril H, Frang AF, D R: Learning biomarker models for progression estimation of Alzheimer’s disease. Medical Image Analysis 2014.

44.   Szokol K, Heuser K, Tang W, Jensen V, Enger R, Bedner P, Steinhauser C, Tauboll E, Ottersen O, E N: Augmentation of Ca2+ signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy. Frontiers in Cellular Neuroscience 2015.

45.   Takalo M, Haapasalo A, Martiskainen H, Kurkinen K, Koivisto H, Miettinen P, Khandelwal V, Kemppainen S, Kaminska D, Makinen Pet al: High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status. Journal of Nutritional Biochemistry 2014, 25(6):634-641.

46.   Tang W, Szokol K, Jensen V, Enger R, Trivedi C, Hvalby O, Helm P, Looger L, Sprengel R, Nagelhus E: Stimulation-Evoked Ca2+ Signals in Astrocytic Processes at Hippocampal CA3-CA1 Synapses of Adult Mice Are Modulated by Glutamate and ATP. Journal of Neuroscience 2015, 35(7):3016-3021.

47.   Thomas J, Brier M, Bateman R, Snyder A, Benzinger T, Xiong C, Raichle M, Holtzman D, Sperling R, Mayeux R: Functional Connectivity in Autosomal Dominant and Late-Onset Alzheimer Disease. Jama Neurology 2014, 71(9):1111-1122.

48.   van Engelen A, Niessen W, Klein S, Groen H, Verhagen H, Wentzel J, van der Lugt A, de Bruijne M: Atherosclerotic Plaque Component Segmentation in Combined Carotid MRI and CTA Data Incorporating Class Label Uncertainty. Plos One 2014, 9(4).

49.   Verlinden V, van der Geest J, de Groot M, Hofman A, Niessen W, van der Lugt A, Vernooij M, Ikram M: Structural and Microstructural Brain Changes Predict Impairment in Daily Functioning. American Journal of Medicine 2014, 127(11):1089-+.

50.   Young A, Oxtoby N, Daga P, Cash D, Fox N, Ourselin S, Schott J, Alexander D: A data-driven model of biomarker changes in sporadic Alzheimer's disease. Brain 2014, 137:2564-2577.

51.   Young A, Oxtoby N, Daga P, Cash D, Fox N, Ourselin S, Schott J, Alexander D, Neuroimaging AsD, Neuroimaging AsD: A data-driven model of biomarker changes in sporadic Alzheimer's disease. Brain 2014, 137:2564-2577.

Conferences

52.   Beltrachini L, De Marco M, Frangi A, Taylor Z, Venneri A: Integration of cognitive tests and Resting State fMRI indices for the identification of amnestic Mild Cognitive Impairment. . In: Alzheimer’s Association International Conference: 12-17 July 2014; Copenhagen; 2014.

53.   Beltrachini L, Taylor Z, Frangi A: A parametrical finite element formulation of the Bloch Torrey equation for NMR applications. In: Proc of the ISMRM 20th Annual Scientific Meeting of the British: 4th – 5th September 2014 2014; Edinburgh; 2014: , p.132.

54.   Burgos N, Cardoso MJ, Thielemans K, Duncan JS, Atkinson D, Arridge SR, Hutton BF, Ourselin S: Attenuation Correction Synthesis for Hybrid PET-MR Scanners: Validation for Brain Study Applications. In: PET MR conference PSMR 2014: 19 - 21 May 2014; Kos island - Greece; 2014.

55.   Carole H, Sudre M, Cardoso C, Ourselin S: Bilayered Anatomically-constrained Split-and-Merge Expectation Maximisation Algorithm (BiASM) for Brain Segmentation. In: SPIE Medical Imaging: 15-20 February 2014; San Diego, California, USA; 2014.

56.   Carole H, Sudre M, Cardoso J, Ourselin S: Bilayered Anatomically-constrained Split-and-Merge Expectation Maximisation Algorithm (BiASM) for Brain Segmentation. In: SPIE Medical Imaging: 15-20 February 2014; San Diego, California, USA; 2014.

57.   Cremers L, De Groot M, Hofman A, Krestin G, Van der Lugt A, Niessen W, Ikram M, Vernooij M: White matter degeneration in aging; a longitudinal diffusion MRI analysis. In: Alzheimer's Association International Conference: 13-17 July 2014; Copenhagen; 2014.

58.   De Marco M, Meneghello F, Venneri A: ‘O’ blood type as protection factor against cognitive decline: a Voxel-Based Morphometry exploratory study. . In: Societa’ Italiana Neurologia delle Demenze Annual Conference: 26-28 March 2015; Genoa (Italy) 2015.

59.   De Marco M, Meneghello F, Vallelunga A, Duzzi D, Pilosio C, Rigon J, Venneri A: Patterns of Hippocampus Functional Connectivity in APOE ε4 Carriers with Mild Cognitive Impairment. In: Alzheimer’s Association International Conference: 12-17 July 2014; Copenhagen (Denmark); 2014.

60.   De Marco M, Meneghello F, Vallelunga A, Duzzi D, Pilosio C, Rigon J, Venneri A: Patterns of Hippocampus Functional Connectivity in APOE ε4 Carriers with Mild Cognitive Impairment. In: Alzheimer’s Research UK Yorkshire Branch: 24 Oct 2014; Sheffield, UK; 2014.

61.   De Marco M, Rigon J, Pilosio C, Meneghello F, Venneri A: Cognitive Stimulation Regulates Functional Connectivity in Mild Cognitive Impairment. In: Organization for Human Brain Mapping International Conference: 8-12 June 2014; Hamburg (Germany); 2014.

62.   De Marco M, Vallelunga A, Duzzi D, Meneghello F, Venneri A: Functional connectivity of the claustrum in mild cognitive impairment and the impact of the ApoE ε4 allele. . In: American Academy of Neurology Annual Meeting: 18-25 April 2015; Washington (USA); 2015.

63.   De Marco M, Vallelunga A, Meneghello F, Mitolo M, Venneri A: Apolipoprotein ɛ4 Allele Modulates Functional Connectivity in Mild Cognitive Impairment. In: Societa’ Italiana Neurologia delle Demenze Junior Annual Conference: 21-23 Jan 2015; Brixen, Italy; 2015.

64.   Lötjönen J, Ledig C, Koikkalainen J, Wolz R, Thurfjell L, Soininen H, Ourselin S, Rueckert D: Extended Boundary Shift Integral. In: IEEE International Symposium on Biomedical Imaging: April 29-May 2 2014; Beijing, China; 2014.

65.   Markiewicz P, Thielemans K, Burgos N, Manber R, Jiao J, Barnes A, Atkinson D, Arridge SR, Hutton BF, Sébastien Ourselin: Image reconstruction of mMR PET data using the open source software STIR. In: PET MR conference (PSMR 2014): 19 - 21 May 2014; Kos island - Greece; 2014.

66.   McGrath DM, Frangi A, Wilkinson ID, Taylor ZA: Modelling skull dynamics during brain magnetic resonance elastography to evaluate wave delivery strategies. In.

67.   McGrath DM, Ravikumar N, Frangi A, Wilkinson ID, Taylor ZA: Magnetic resonance elastography in the brain: an in silico study on the influence of cranial anatomy. In.

68.   Mendelson AF, Zuluaga MA, Thurfjell L, Hutton BF, Ourselin S: The Empirical Variance Estimator for Computer Aided Diagnosis: Lessons for Algorithm Validation. In: Medical Image Computing and Computer Assisted Intervention (MICCAI),: September 14-18 2014; Boston, USA; 2014.

69.   Modat M, Cash D, Daga P, Winston G, Duncan J, Ourselin S: A symmetric block-matching framework for global registration. In: SPIE Medical Imaging: 15-20 February 2014; San Diego, California, USA; 2014.

70.   Modat M, Simpson I, Cardoso J, Cash D, Toussaint N, Fox N, Ourselin S: Simulating neurodegeneration through longitudinal population analysis of structural and diffusion weighted MRI data. In: Medical Image Computing and Computer Assisted Intervention (MICCAI): September 14-18 2014; Boston, USA; 2014.

71.   Ravikumar N, Castro I, Frangi A, Taylor Z: 3D active shape models of human brain structures: application to patient-specific mesh generation. In: SPIE Medical Imaging: 21-26 Feb 2015; Orlando, Florida; 2015.

72.   Sudre C, Cardoso MJ, Bouvy W, Biessels GJ, Barnes J, Ourselin S: Bayesian model selection for pathological data. In: Medical Image Computing and Computer Assisted Intervention (MICCAI): September 14-18 2014; Boston, USA; 2014.

73.   Vardakis J, Chou D, Guo L, B, Tully B, Ventikos Y: Investigating Cerebral Oedema using Poroelasticity. In: 3rd International CSF Dynamics Symposium: July 9 - 10 2015; Amiens, France; 2015.

74.   Vardakis J, Chou D, Guo L, Ventikos Y: Multicompartmental Poroelasticity for the Integrative modelling of periventricular lucency. In: 4th International Conference on Computational and Mathematical Biomedical Engineering: 29 June - 1 July 2015; Paris, France; 2015.

75.   Vardakis J, Chou D, Tully B, Ventikos Y: A CFD and FEM Approach to a Multicompartmental Poroelastic Model for CSF Production and Circulation with Applications in Hydrocephalus Treatment and Cerebral Oedema. In: 4th Micro and Nano Flows Conference: 7-10 September 2014; University College London, UK.; 2014.

76.   Vardakis J, Chou D, Tully B, Ventikos Y: Multicompartmental Poroelasticity for the Integrative Modelling of Fluid Transport in the Brain. In: 9th European Solid Mechanics Conference: July 6-10 2015; Leganés-Madrid, Spain; 2015.

77.   Vardakis JC, Chou D, Tully BJ, Ventikos Y: Exploring a Multicompartmental Poroelastic Model for the Integrative Modelling of Fluid Transport. In: 7th World Congress of Biomechanics Boston: 6th to 11th of July 2014; Massachusetts, USA; 2014.

78.   Vardakis JC, Chou D, Ventikos Y: Understanding Hydrocephalus using a Multicompartmental Poroelasticity Model. In: The 18th International Conference on Finite Elements in Flow Problems: 16-18 March 2015; Taipei, Taiwan; 2015.

79.   Venneri A: Reinterpreting the role of neuropsychology in neurodegeneration and dementia: a personal perspective. In: Societa’ Italiana Neurologia delle Demenze Annual Conference: 26-28 March 2015; Genoa (Italy) 2015.

80.   Zagorchev L, Stehle T, Meyer C, Wenzel F, Popov V, Hakky M, Flacke S: Shape-constrained Deformable Segmentation for Alzheimer’s Disease. In: OHBM 2014 Annual Meeting: June 8-12 2014; Hamburg, Germany; 2014.

81.   Zuluaga MA, Rodionov R, Nowell M, Achhala S, Zombori G, Cardoso MJ, Miserocchi A, McEvoy AW, Duncan JS, Ourselin S: SEEG Trajectory Planning: Combining Stability, Structure and Scale in Vessel Extraction. In: Medical Image Computing and Computer Assisted Intervention (MICCAI): September 14-18 2014; Boston, USA 2014.

Workshops

82.   Huizinga W, Metz CT, Poot DHJ, de Groot M, Leemans A, Niessen WJ, Klein S: Groupwise registration for correcting subject motion and eddy current distortions in diffusion MRI using a PCA based dissimilarity metric. In: Workshop on Computational Diffusion MRI and Brain Connectivity, MICCAI,: September 22 - 26 2013; Nagiya, Japan; 2013.

83.   Huizinga W, Poot DHJ, Guyader J, Smit H, van Kranenburg M, van Geuns RJM, Uitterdijk, van Beusekom HMM, Coolen BF, Leemans Aet al: Non-rigid groupwise image registration for motion compensation in quantitative MRI. In: 6th International Workshop, WBIR: July 7-8 2014; London, UK; 2014.

84.   Huizinga W, Poot DHJ, Klein S: Fast Multidimensional B-spline Interpolation using Template Metaprogramming. In: 6th International Workshop, WBIR 2014: July 7-8 2014; London, UK; 2014.

Thesis

85.   Muñoz-Ruiz M A, Disease State Index and neuroimaging in frontotemporal dementia, Alzheimer's disease and mild Cognitive impairment (doctoral thesis)